Endocrine Abstracts

Background: Adipose tissue dysfunction could partially explain the well-demonstrated association between obesity and survival in breast cancer (BC). Oestrogen and glucocorticoid concentrations and their respective activation enzymes, oestrogenic 17β-hydroxysteroid dehydrogenases (17βHSDs) and aromatase, and 11βHSD1 are increased in adipocyte hyperplasia and hypertrophy, supporting the hypothesis of a potential role for locally generated steroids in obesity-assoc...

BackgroundObesity is closely associated with impaired adipose tissue function. Although bariatric surgery is the treatment of choice for severe obesity and its related conditions, there are conflicting data on the reversal of adipose tissue dysfunction after surgery-induced weight loss. We hypothesise that local steroid hormone availability influences fat deposition or mobilisation and that these changes track with weight loss improvements, because plasm...